The London System is a setup rather than a single line. White plays d4, develops the dark-squared bishop to f4 early, and then builds a pyramid with e3 and c3, with the knights on f3 and d2 and the light-squared bishop on d3.
Its appeal is that the setup barely changes: against ...d5, against ...Nf6 and ...g6, and against most other replies White can follow the same plan. The key detail is move order. The bishop goes to f4 before e3, so it is not shut in behind its own pawns, as it is in the Colle System.
Once seen as a quiet club opening, it became a serious top-level weapon in the 2010s, with Magnus Carlsen among the grandmasters who play it regularly.