The Sicilian Defense starts 1.e4 c5. Instead of meeting e4 with a central pawn, Black controls d4 with the c-pawn. If White opens the centre with Nf3 and d4, Black exchanges the c-pawn for the d-pawn and keeps two central pawns (d and e) against White's one.
That imbalance is the whole point. White usually gets more space and quicker development. Black gets the half-open c-file, a sound pawn majority in the centre and long-term chances in the endgame. The positions are sharp, often with the kings castled on opposite sides.
The main systems are the Najdorf (5...a6), the Dragon (5...g6), the Sveshnikov (...Nc6 and ...e5), the Scheveningen and the Taimanov. White can avoid the Open Sicilian with the Alapin (2.c3), the Rossolimo (2...Nc6 3.Bb5) or the Smith-Morra Gambit (2.d4 cxd4 3.c3).