Berlin Defense (3...Nf6)
1.e4 e5 2.Nf3 Nc6 3.Bb5 Nf6 4.O-O Nxe4 5.d4 Nd6 6.Bxc6 dxc6 7.dxe5 Nf5 8.Qxd8+ Kxd8
Black ignores the bishop and counter-attacks e4. After 4.O-O Nxe4 5.d4 Nd6 6.Bxc6 dxc6 7.dxe5 Nf5 8.Qxd8+ Kxd8 the queens are off. Black has lost the right to castle but has the bishop pair and a very solid position. Vladimir Kramnik used it to take the world title from Garry Kasparov in 2000.